Thyroid problems can cause symptoms like fatigue, weight gain, brain fog, and mood swings, yet many people are told their lab results are “normal.” This happens because some doctors only check TSH (thyroid-stimulating hormone), which does not give the full picture of thyroid health. A deeper look at thyroid function requires additional testing. Here are three must-have lab tests that are often missed but can provide important answers.
1. Free T3 and Free T4
TSH tells the thyroid to make hormones, but it does not show if the body is using those hormones correctly. Free T3 and Free T4 measure the actual thyroid hormones available for the body to use. Free T4 is the storage form, while Free T3 is the active form that helps with energy, metabolism, and brain function. Low Free T3 can cause fatigue, weight gain, and depression, even if TSH is in the normal range. Checking both Free T3 and Free T4 gives a better understanding of how well the thyroid is functioning.
2. Reverse T3
Reverse T3 (RT3) is a lesser-known but important test. When the body is under stress or has inflammation, it can convert T4 into Reverse T3 instead of the active Free T3. Reverse T3 blocks the thyroid from working properly, leading to symptoms like exhaustion, brain fog, and difficulty losing weight. High Reverse T3 can mean the body is struggling with stress, poor gut health, or chronic illness, making it an important test for anyone with lingering thyroid symptoms.
3. Thyroid Antibodies (TPO and TG Antibodies)
Many thyroid problems are caused by autoimmune conditions like Hashimoto’s thyroiditis. Thyroid Peroxidase (TPO) and Thyroglobulin (TG) antibodies test for autoimmune activity against the thyroid. Hashimoto’s can start years before TSH becomes abnormal, so testing for antibodies can help catch thyroid disease early. Without this test, many people go undiagnosed and continue to suffer from symptoms.
Getting the Right Testing for Thyroid Health
A full thyroid panel, including Free T3, Free T4, Reverse T3, and Thyroid Antibodies, provides a clearer picture of thyroid function. Without these tests, thyroid imbalances can go unnoticed, leaving symptoms untreated. Proper lab work helps create a personalized treatment plan to restore energy, metabolism, and overall well-being.